What Is Triethylene Glycol Monomethyl Ether (TEGMME)?
Triethylene Glycol Monomethyl Ether (TEGMME, CAS 112-35-6) - also known as Methyl Triglycol or 2-[2-(2-Methoxyethoxy)ethoxy]ethanol - is a colorless, low-odor liquid belonging to the glycol ether E-series family. With molecular formula C₇H₁₆O₄ (MW 164.20 g/mol), TEGMME is the third homolog in the methyl-terminated glycol ether series, featuring three ethyleneoxy units in its backbone - one more than DEGMME and two more than EGMME.
This extended molecular chain gives TEGMME its defining performance characteristics: a high boiling point (230–250 °C), very low vapor pressure, high flash point (~127 °C), and slow evaporation rate. These properties translate into exceptional open-time extension in coatings, prolonged cleaning contact time in industrial degreasing, and reduced flammability risk in processing environments - making TEGMME the preferred glycol ether solvent when maximum working time and process safety are both required. It is completely miscible with water, alcohols, ketones, esters, and aromatic hydrocarbons.
Beyond its solvent role, TEGMME is a strategically important chemical intermediate: it is converted to Amino TEGMME (CAS 6711-56-6) through amination of its terminal hydroxyl group, yielding a monofunctional PEG amine that is a key building block for PEGylation reagents, biopharmaceutical conjugates, and functionalized nanomaterials. Like DEGMME, TEGMME is not classified as a reproductive toxicant and is not subject to EU REACH Annex XVII consumer product restrictions. Sinolook supplies TEGMME at purity ≥99.0% (high-purity ≥99.5% available), ISO 9001 and ISO 14001 certified, with full COA, SDS, and REACH documentation.
Key Performance Advantages of TEGMME
Six functional properties distinguish Triethylene Glycol Monomethyl Ether from lower-chain glycol ether solvents - particularly its combination of ultra-slow evaporation, superior fire safety, and unique role as a pharmaceutical chemical intermediate that has no equivalent in the EGMME or DEGMME series.
🌡️ Highest Boiling Point & Ultra-Slow Evaporation
With a boiling point of 230–250 °C - significantly higher than DEGMME (191–198 °C) and EGMME (124–125 °C) - TEGMME has the slowest evaporation rate in the methyl glycol ether homologous series. This ultra-slow evaporation profile delivers maximum open time in coating applications, longest contact time in industrial cleaning, and minimal solvent loss during high-temperature processing. Particularly valuable in warm or dry application conditions where faster-evaporating solvents cause film defects such as lapping marks, brush drag, and poor leveling.
🔥 Superior Fire Safety - Flash Point ~127 °C
TEGMME's flash point of ~127 °C is among the highest of any commonly used glycol ether solvent - far exceeding DEGMME (88 °C), EGMME (39 °C), and lower-boiling alternatives. This means TEGMME is classified as a combustible liquid under the most conservative GHS criteria, with no flammable liquid classification in most jurisdictions. It significantly simplifies fire safety compliance in industrial cleaning baths, high-solids coating lines, and pharmaceutical manufacturing suites - reducing infrastructure costs and regulatory burden compared to flammable solvent alternatives.
⚗️ Amino TEGMME Precursor for PEGylation Chemistry
TEGMME is the direct precursor for Amino TEGMME (CAS 6711-56-6), produced by amination of the terminal hydroxyl group to yield a primary amine (–NH₂). Amino TEGMME is a critical monofunctional PEG amine widely used in PEGylation chemistry - the process of attaching polyethylene glycol chains to drug molecules to improve solubility, circulation half-life, and bioavailability. It is also used in bioconjugation, polymer-drug conjugates, functionalized nanomaterials, and specialty surfactant synthesis. This downstream application gives TEGMME unique strategic importance as a specialty chemical raw material with no DEGMME or EGMME equivalent.
🔗 Full Water Miscibility & Coupling Power
Like all methyl glycol ether homologs, TEGMME is completely miscible with water in all proportions and simultaneously dissolves a wide range of organic resins, oils, waxes, and polymeric residues. This amphiphilic character - driven by the hydrophilic triethylene glycol backbone and hydrophobic terminal methyl group - makes TEGMME an outstanding coupling solvent in formulations combining aqueous and non-aqueous phases. Essential in waterborne coatings, aqueous cleaning concentrates, and agrochemical EC/SL formulations that must maintain single-phase stability across storage temperature and dilution conditions.
🛡️ Favorable Regulatory Profile - Not Repr. 1B
TEGMME is not classified as a reproductive toxicant (no Repr. 1B or Repr. 2 designation) and is not subject to EU REACH Annex XVII consumer product restrictions - in contrast to EGMME (Repr. 1B, H360D). This benign regulatory classification enables use in pharmaceutical formulations, personal care products, and consumer-facing cleaning products where EGMME is excluded. REACH registered (EC 203-961-6); not SVHC listed. Low vapor pressure further minimizes inhalation exposure risk in industrial handling compared to lower-boiling E-series glycol ethers.
✨ Smooth Sensory Profile in Personal Care
TEGMME's higher molecular weight (164.20 g/mol) and lower volatility compared to EGMME and DEGMME contribute a smoother, less drying, and more substantive skin feel - a sensory characteristic increasingly valued in premium skin care and hair care formulations. It acts simultaneously as solubilizer for fragrances and lipophilic actives, humectant, and texture modifier, delivering multi-functional performance in a single ingredient. Its compatibility with surfactants, thickeners, film-formers, and preservatives commonly used in cosmetic systems further enhances formulation flexibility.
📌 TEGMME vs DEGMME vs EGMME - Methyl Glycol Ether Series Comparison
The three methyl-terminated E-series glycol ethers form a homologous series with progressively higher boiling points, lower vapor pressures, and higher flash points as chain length increases: EGMME (BP 124 °C, FP 39 °C) → DEGMME (BP 191–198 °C, FP 88 °C) → TEGMME (BP 230–250 °C, FP ~127 °C). Select the solvent based on your required evaporation rate and process temperature.
Key regulatory note: EGMME carries Repr. 1B (H360D) classification and EU REACH Annex XVII consumer product restriction; DEGMME and TEGMME do not. For applications requiring the slowest evaporation, highest flash point, and Amino TEGMME downstream chemistry, TEGMME is the definitive choice. All three products are available from Sinolook - contact our technical team for application-specific guidance.
Triethylene Glycol Monomethyl Ether Uses & Applications
TEGMME (CAS 112-35-6) serves as a high-performance solvent, coalescing agent, and chemical intermediate across seven major industrial sectors. Its unique combination of ultra-high boiling point, complete water miscibility, high flash point, and strategic role as an Amino TEGMME precursor positions it as an indispensable solvent in both industrial and life-science applications.
Paints, Coatings & Architectural Finishes
High-boiling coalescing agent and open-time extender in waterborne latex and acrylic coating systems. Gives paint applicators maximum working time on the substrate - critical in warm, dry conditions where faster-evaporating solvents cause lapping marks, brush drag, and leveling defects. Also used in alkyd, epoxy, and polyurethane coatings as a flow modifier and reactive diluent. Achieves smooth, uniform films with strong adhesion in industrial maintenance coatings applied to metal structures, machinery, and pipelines.
Industrial Cleaning & Heavy-Duty Degreasing
Dissolves mineral oils, synthetic lubricants, silicone compounds, polymeric residues, and flux deposits from metal, ceramic, and composite substrates. High flash point (>120 °C) and low vapor pressure make it the preferred alternative to lower-boiling ketones and alcohols in enclosed cleaning systems - reducing VOC emissions and improving operator safety. Used in aqueous and semi-aqueous cleaning systems for PCB assemblies, semiconductor wafers, and precision optical components where prolonged contact time and residue-free evaporation are required.
Pharmaceuticals & Biotechnology
Low-toxicity co-solvent for APIs in oral liquid preparations, topical creams and gels, transdermal patches, and parenteral formulations. Residual solvent levels should be evaluated per ICH Q3C guidelines for the specific dosage form. Beyond direct use, TEGMME is the upstream precursor for Amino TEGMME (CAS 6711-56-6) - a critical PEG amine building block for PEGylation reagents, biopharmaceutical drug-polymer conjugates, and functional polymers for drug delivery systems. Pharmaceutical-grade TEGMME (≥99.5%) with dedicated documentation available on request.
Personal Care & Cosmetics
Solubilizer, humectant, and texture modifier in skin creams, body lotions, facial serums, hair conditioners, and nail care products. Solubilizes both hydrophilic and lipophilic actives - fragrances, botanical extracts, vitamins - in a single-phase system, simplifying formulation and improving product stability. Higher molecular weight contributes a smoother, less-drying skin feel compared to lower-chain glycol ethers, valued in premium skin care. Compatible with anionic, nonionic, and amphoteric surfactant systems, thickeners, film-formers, and common cosmetic preservatives.
Electronics & Semiconductor Manufacturing
Applied in photoresist stripping formulations, post-CMP cleaning agents, and specialty flux removers in semiconductor and PCB manufacturing. High boiling point supports effective cleaning at elevated process temperatures without premature evaporation and residue re-deposition - a critical quality concern in semiconductor fabrication. Low ionic contamination and broad materials compatibility (metals, polymers, ceramics) enable use in precision cleaning of wafers, optical components, and assembled PCBs where lower-boiling solvents would flash off prematurely.
Agrochemical Formulations
Carrier and co-solvent in emulsifiable concentrates (EC), suspension concentrates (SC), and soluble liquid (SL) formulations of herbicides, insecticides, and fungicides. Improves solubility of active ingredients that are difficult to formulate with lower-boiling solvents, and enhances spreading and penetration on crop surfaces for improved biological efficacy. Water miscibility enables stable single-phase concentrates combining hydrophilic and lipophilic components - with minimal evaporative loss during manufacture and storage.
Chemical Synthesis & Specialty Intermediates
High-boiling polar reaction solvent for synthesis requiring elevated temperatures where lower-boiling solvents would evaporate. Intermediate in the manufacture of surfactants, specialty polymers, and textile/leather auxiliaries. Key precursor for Amino TEGMME (CAS 6711-56-6) via amination of terminal hydroxyl group - used in PEGylation reagent synthesis, bioconjugation chemistry, and functionalized nanomaterial production. Also serves as a carrier fluid in hydraulic and drilling fluids and as a co-solvent in textile processing auxiliaries.
Technical Specifications & COA
Sinolook's Triethylene Glycol Monomethyl Ether is produced under strict quality control with every batch tested against the parameters below. A full Certificate of Analysis (COA), TEGMME SDS / MSDS (GHS-compliant), and Technical Data Sheet (TDS) are issued with every shipment. High-purity grade (≥99.5%) for pharmaceutical and electronic applications is available upon request.
TEGMME (Methyl Triglycol, CAS 112-35-6) - Quality Specifications & Typical COA
| Parameter | Specification | Typical COA Result |
|---|---|---|
| Appearance | Colorless transparent liquid, free of suspended matter | Clear colorless liquid |
| Purity (GC), wt% | ≥99.0% | 99.2 – 99.5% |
| Water Content (Karl Fischer), wt% | ≤0.1% | 0.03 – 0.07% |
| Density (20 °C), g/cm³ | 1.046 – 1.052 | 1.048 – 1.050 |
| Boiling Point, °C | 230 – 250 °C (1 atm) | 235 – 245 °C |
| Flash Point (closed cup), °C | ≥120 °C | ~127 °C |
| Color (Pt-Co / APHA) | ≤10 | ≤5 |
| Viscosity (25 °C), mPa·s | ~6.0 | 5.5 – 6.5 |
| Acidity (as acetic acid), wt% | ≤0.005% | <0.002% |
| Residue on Evaporation, wt% | ≤0.01% | <0.005% |
High-Purity Grade (≥99.5%): Available for pharmaceutical, biotechnology, and electronic applications requiring tighter purity specifications. DMF support files and GMP compliance declarations available for pharmaceutical customers upon request. Amino TEGMME (CAS 6711-56-6) is also available as a derivative product - contact our team for specifications and availability.
TEGMME SDS, Safety & Regulatory
Triethylene Glycol Monomethyl Ether has an excellent safety and regulatory profile. Its high flash point (~127 °C) means it is not classified as a flammable liquid under GHS criteria in most jurisdictions, it is not classified as a reproductive toxicant, and it is not subject to EU REACH Annex XVII consumer product restrictions. Low vapor pressure minimizes inhalation exposure under standard industrial conditions. TEGMME SDS / MSDS are GHS-compliant and available in English, German, French, Spanish, and Chinese.
| Safety / Regulatory Parameter | Value / Notes |
|---|---|
| GHS Classification | Eye Irrit. 2; Skin Irrit. 2 - not classified as flammable liquid or reproductive toxicant |
| GHS Signal Word | WARNING |
| Flash Point | ~127 °C (closed cup) - not classified as flammable liquid under GHS; standard combustible liquid storage conditions apply |
| Reproductive Toxicity | Not classified - no Repr. 1B/2 designation; no EU REACH Annex XVII consumer restriction |
| PPE Recommended | Safety glasses; nitrile or neoprene gloves; avoid prolonged skin and eye contact; adequate ventilation in enclosed workspaces |
| REACH / SVHC Status | ECHA registered (EC No. 203-961-6); Not SVHC listed; No Annex XVII restriction; REACH compliance letter available |
| Additional Compliance | RoHS declaration, Prop 65 statement, and pharmaceutical DMF support files available upon request |
| Storage | Cool, dry, well-ventilated area; 5–35 °C; sealed containers; away from strong oxidizers, acids, and bases; shelf life 24 months |
| SDS Languages Available | English, German, French, Spanish, Chinese |
| Request SDS / COA / TDS | sales@sinolookchem.com or WhatsApp +86 134 0071 5622 - issued within 24 hours |
TEGMME Price, Packaging & B2B Supply
Triethylene glycol monomethyl ether price depends on grade (standard ≥99.0% / high-purity ≥99.5%), order volume, packaging, and delivery terms. Sinolook operates as a direct manufacturer with scalable production capacity, offering transparent pricing with volume discount tiers and long-term fixed-price supply contracts. Request a customized TEGMME price quote - response within 24 hours.
| Order Volume | Packaging | Included Services |
|---|---|---|
| 1 – 5 kg (Sample) | Sample bottle / small drum | COA, TEGMME SDS/MSDS, TDS; nominal charge refundable against first commercial order |
| 1 MT – 20 MT (Regular) | 200 kg iron drums / 1,000 kg IBC tanks | Volume discount; dedicated account manager; full export documentation; third-party inspection available |
| 20 MT+ (Bulk / Contract) | IBC tanks / ISO tank containers (bulk) | Best TEGMME price; fixed-price annual supply contract; reserved production capacity; 24/7 technical support |
📦 MOQ
1 MT standard grade. Qualification samples (1–5 kg) at nominal charge, refundable against first commercial order.
🚢 Delivery Terms
FOB, CFR, CIF, DAP, DDP. Ex-Shanghai, Tianjin, Qingdao, Guangzhou. North America, Europe, SEA, Middle East, Africa.
⏱ Lead Time
Price quote within 24 hours. Production and export: 10–15 business days from order confirmation. Urgent orders accommodated.
🔍 Inspection
Third-party inspection by SGS or Intertek available at buyer's cost. Pre-shipment samples and COA provided for all orders.
- ✓ ISO 9001 & ISO 14001 certified - every batch QC tested for GC purity, Karl Fischer, density, color, flash point, viscosity, and acidity
- ✓ Full export documentation: COA, TEGMME SDS/MSDS, TDS, Certificate of Origin, packing list, commercial invoice, fumigation certificate
- ✓ EU REACH compliance letter (EC No. 203-961-6), SVHC declaration, RoHS declaration, and Prop 65 statement available on request
- ✓ Pharmaceutical-grade TEGMME (≥99.5%) with DMF support files and GMP declarations available for life-science customers
- ✓ Amino TEGMME (CAS 6711-56-6) available as derivative product - contact our team for specifications, pricing, and availability
- ✓ Technical support: coalescing agent optimization, solvent blend design, TEGMME vs DEGMME selection, pharmaceutical formulation guidance
Frequently Asked Questions About TEGMME
Technical and commercial questions about Triethylene Glycol Monomethyl Ether (CAS 112-35-6) from B2B buyers in coatings, pharmaceuticals, electronics, and specialty chemical industries.
What is Triethylene Glycol Monomethyl Ether (TEGMME) and what is it used for?
Triethylene Glycol Monomethyl Ether (TEGMME, CAS 112-35-6) - also known as Methyl Triglycol - is a high-boiling, low-volatility glycol ether solvent and chemical intermediate completely miscible with water. Primary TEGMME uses include: coalescing agent / open-time extender in waterborne and solvent-borne coatings (especially architectural and industrial maintenance paints); heavy-duty degreasing solvent with low VOC and high flash point; pharmaceutical co-solvent for oral liquids, topical gels, and transdermal formulations; personal care solubilizer and texture modifier; electronics cleaning solvent for photoresist stripping and post-CMP cleaning; and as the direct precursor for Amino TEGMME used in PEGylation chemistry and biopharmaceutical synthesis.
What are the synonyms for TEGMME?
TEGMME is known by several trade and chemical names: Methyl Triglycol (most common trade name), 2-[2-(2-Methoxyethoxy)ethoxy]ethanol (IUPAC name), Triglycol Monomethyl Ether, and Methyl Carbitol Extended. All refer to the same compound with CAS 112-35-6, EINECS 203-961-6. In procurement documents, "TEGMME" and "Methyl Triglycol" are both widely used; the IUPAC name appears in REACH and regulatory documentation.
What is the difference between TEGMME and DEGMME?
TEGMME (CAS 112-35-6) has one additional ethyleneoxy unit compared to DEGMME (CAS 111-77-3), resulting in a higher molecular weight (164.20 vs 120.15 g/mol), higher boiling point (230–250 °C vs 191–198 °C), higher flash point (~127 °C vs ~88 °C), lower vapor pressure, and slower evaporation. TEGMME is preferred when maximum open time, highest fire safety margin, or compatibility with high-temperature processes is required. TEGMME also has a unique application as the precursor for Amino TEGMME in PEGylation chemistry - with no DEGMME equivalent. DEGMME is lower in cost and preferred where moderate evaporation rate and lower viscosity are sufficient. Both are available from Sinolook.
What is Amino TEGMME and how is it related to TEGMME?
Amino TEGMME (Amino Triethylene Glycol Monomethyl Ether, CAS 6711-56-6) is produced by converting the terminal hydroxyl group of TEGMME to a primary amine (–NH₂) through amination. The resulting compound is a monofunctional PEG amine widely used in PEGylation chemistry - attaching PEG chains to drug molecules to improve solubility, circulation half-life, and bioavailability - as well as in bioconjugation, polymer-drug conjugate synthesis, and functionalized nanomaterial production. Sinolook supplies Amino TEGMME as a derivative product alongside TEGMME. Contact our team for specifications, purity grades, and pricing.
Is TEGMME safe for pharmaceutical formulations?
Yes. TEGMME has a well-established low-toxicity profile and is used in pharmaceutical formulations under appropriate regulatory frameworks. Residual solvent limits should be evaluated in accordance with ICH Q3C guidelines for the specific dosage form and administration route. Sinolook can supply pharmaceutical-grade TEGMME (≥99.5% purity) with GMP-aligned quality documentation, DMF support files, and GMP compliance declarations. Not classified as a reproductive toxicant and not subject to EU REACH Annex XVII restrictions, supporting its use in pharmaceutical and consumer health product manufacturing.
Can Sinolook provide REACH, RoHS, and Prop 65 compliance documentation?
Yes. TEGMME (CAS 112-35-6, EC No. 203-961-6) is registered under EU REACH and is not classified as an SVHC. Sinolook provides REACH compliance letters, RoHS declarations, California Prop 65 statements, and other application-specific regulatory documentation as required. All compliance documentation is issued with every commercial shipment at no additional charge. Contact sales@sinolookchem.com to request documentation in advance of your first order.
How do I get a TEGMME price quote or sample?
Qualification samples (1–5 kg) are available prior to commercial orders at a nominal charge refundable against the first order. Contact us with your grade, quantity, destination, and Incoterms preference.
- Step 1: Contact us with your requirements - grade (standard ≥99.0% or high-purity ≥99.5%), quantity, packaging, delivery terms, and destination port.
- Step 2: Receive a detailed TEGMME price quote within 24 hours, including specifications, lead time, and documentation list.
- Step 3: Request a qualification sample (1–5 kg) for application testing and quality verification before commercial order placement.
- Step 4: Confirm your order - Sinolook handles production scheduling, packaging, full export documentation (COA, SDS, Certificate of Origin, packing list), and freight booking.
- Step 5: Receive your shipment on time with complete traceability documentation. Third-party inspection (SGS/Intertek) and pharmaceutical DMF files available upon request.
Hot Tags: triethylene glycol monomethyl ether, China triethylene glycol monomethyl ether manufacturers, suppliers
