Pyrrolidine (CAS 123-75-1) - High-Purity ≥99%
Industrial · Reagent · Cosmetic grade, direct from BDO-integrated Chinese manufacturer. C₄H₉N · MW 71.12 · UN1922.
📦 Product Overview
Pyrrolidine (CAS 123-75-1) is a five-membered saturated nitrogen heterocycle - also known as tetrahydropyrrole or azolidine - supplied by Sinolook Chemical at high purity (≥99%) directly from BDO-integrated Chinese manufacturers. It is one of the most versatile fine-chemical intermediates in the modern chemistry industry, serving as the upstream raw material for pharmaceutical APIs, polyvinylpyrrolidone (PVP) polymer chains, personal-care actives, agrochemical intermediates, rubber accelerators, analytical chelating agents (APDC), and asymmetric organocatalysts. We supply pyrrolidine in three grades - industrial, reagent, and cosmetic - with full COA, SDS, REACH-supported documentation, and UN1922-compliant packaging from 200 kg drums to ISO-tank shipments.
📊 Technical Specifications
| Parameter | Value | Test Method |
|---|---|---|
| Chemical Name | Pyrrolidine | - |
| Synonyms | Tetrahydropyrrole; Azolidine; Azacyclopentane | - |
| CAS Number | 123-75-1 | - |
| EC Number | 204-648-7 | - |
| Molecular Formula | C₄H₉N | - |
| Molecular Weight | 71.12 g/mol | - |
| Purity (assay) | ≥ 99.5% | GC area % |
| Appearance | Colorless to pale yellow liquid | Visual |
| Boiling Point | 86–88 °C | @ 760 mmHg |
| Melting Point | −63 °C | - |
| Density (20 °C) | 0.852 g/mL | Pycnometer |
| Refractive Index (n²⁰D) | 1.443 | Refractometer |
| Flash Point | 3 °C (closed cup) | ASTM D93 |
| Water Content (KF) | ≤ 0.1% | Karl Fischer |
| Color (APHA) | ≤ 30 | ASTM D1209 |
| n-Butylamine residual | ≤ 0.1% | GC |
| 2-Pyrrolidone residual | ≤ 0.2% | GC |
| Heavy metals total | ≤ 10 ppm (Pb ≤ 5 ppm) | ICP-MS |
| Solubility | Miscible with water; soluble in alcohols, ether | - |
| UN Number | UN1922 (Class 3, PG II, Subsidiary 8) | - |
📥 Detailed COA & SDS for each batch are available on request - please use the inquiry form below or contact us via WhatsApp / WeChat / Email.
🏷️ Three Grades - One Supplier
Sinolook Chemical supplies pyrrolidine in three quality tiers, allowing buyers to consolidate procurement across industrial polymer feedstock, pharmaceutical-intermediate, and cosmetic-grade applications:
For PVP & Polymer Manufacture
≥99.0% purity, water ≤0.5%. Ideal upstream feedstock for 2-pyrrolidone, NVP and PVP value chain. ISO-tank capable.
For API & APDC Synthesis
≥99.5% purity, low n-butylamine & 2-pyrrolidone, controlled metals. Suitable for pharmaceutical intermediates & APDC analytical reagent manufacture.
For Personal Care Actives
≥99.5% purity, full BSE/TSE-free, GMO-free, allergen statements. INCI-compliant for hydroxyethyl pyrrolidine, DHEP & cosmetic-derivative production.
🏭 Major Applications
Procyclidine, captopril, sunitinib, vildagliptin, larotrectinib, ozanimod and many CNS & oncology APIs.
Hydroxyethyl pyrrolidine, DHEP topical anti-inflammatory, hair-growth actives, PVP/NMP precursor.
Upstream of NVP monomer & polyvinylpyrrolidone (PVP) - pharma binder, hairspray fixer, contact-lens hydrogel.
Building block for modern herbicides, insecticides & fungicides leveraging the metabolically stable pyrrolidine ring.
Upstream of APDC (ammonium pyrrolidine dithiocarbamate) for trace-metal AAS & ICP-MS sample preparation.
Pyrrolidine dithiocarbamates as ultra-fast vulcanization accelerators & antioxidant additives.
Parent of L-proline, Hayashi-Jørgensen catalyst & chiral pyrrolidine organocatalysts (Nobel Prize 2021).
Stork enamine reaction with ketones, N-Boc / N-methyl / N-ethyl protected derivatives, late-stage amine couplings.
📦 Packaging & Shipping
| Container | Net Content | UN Spec | Typical MOQ |
|---|---|---|---|
| Steel pail (sample) | 25 kg | UN 1A2 | 1 pail |
| Steel drum (epoxy-lined) | 170–200 kg | UN 1A1 | 1 drum (most common) |
| Composite IBC | 800–1000 kg | UN 31HA1 | 1 IBC |
| SS composite IBC | 1000 kg | UN 31A | 1 IBC |
| ISO tank container | 18,000–22,000 kg | UN T7 / T11 | 1 tank |
All bulk containers are nitrogen-blanketed at filling for prolonged shelf life (≥24 months under proper storage). UN1922-compliant labeling, multilingual SDS, and full export documentation (Commercial Invoice, Packing List, B/L, Dangerous Goods Declaration, Certificate of Origin, REACH letter) are prepared in-house for shipments to 50+ countries via sea freight, air freight (samples only), or road freight (regional).
📋 Documentation Package (Included with Every Shipment)
🛡️ Storage & Safety
Pyrrolidine is classified under UN1922 as a Class 3 Flammable Liquid, Packing Group II, with Class 8 Corrosive subsidiary risk (flash point 3 °C). Handle with full PPE in well-ventilated areas. Store at 2–25 °C in tightly sealed UN-spec containers under nitrogen blanket where possible; segregate from oxidizers, strong acids, ketones, aldehydes and nitrosating agents.
- Storage temperature: 2–25 °C, dry, well-ventilated
- Shelf life: ≥24 months under nitrogen blanket in original sealed containers
- Container materials: 304/316 stainless steel, glass, PTFE - avoid copper, aluminum, natural rubber long-term
- Required PPE: butyl rubber gloves (16+ mil), chemical splash goggles, face shield for transfer operations, AB cartridge respirator if odor detected
- Eyewash & safety shower: within 10 seconds of any handling area
📚 Knowledge Hub - Pyrrolidine Technical Resources
Sinolook Chemical maintains a comprehensive technical reference library on pyrrolidine chemistry. Browse our 12-article series for in-depth information across structure, chemistry, applications, safety, and sourcing:
❓ Frequently Asked Questions
Q1: What is the CAS number of pyrrolidine?
Pyrrolidine has CAS Registry Number 123-75-1, EC Number 204-648-7, molecular formula C₄H₉N, molecular weight 71.12 g/mol. It is also known as tetrahydropyrrole or azolidine.
Q2: What is your pyrrolidine purity specification?
Standard supply is ≥99.5% by GC. Industrial grade ≥99.0%. Reagent and cosmetic grades carry tighter limits on water (≤0.1% KF), color (≤30 APHA), n-butylamine (≤0.1%), 2-pyrrolidone (≤0.2%), and total heavy metals (≤10 ppm).
Q3: What's the MOQ for pyrrolidine?
Sample shipments start from 100 g – 1 kg. Production orders typically begin at 1 drum (200 kg). For bulk volumes: 1 IBC (1000 kg) or 1 ISO tank (~18-22 t). Sample-then-production ramp-up is welcomed for new accounts.
Q4: Can you provide SDS and COA?
Yes - every shipment includes a batch-specific COA signed by our QC manager and a multi-language SDS (English, Chinese, Spanish, French, German, Japanese, Russian on request). Supplementary BSE/TSE-free, GMO-free, and allergen statements are provided for cosmetic-grade orders.
Q5: How is pyrrolidine shipped internationally?
Under UN1922 (Class 3 Flammable, PG II, Class 8 Corrosive subsidiary). Sea freight in UN-spec drums or IBCs is the standard B2B method. Air freight is available for samples only (max 5 L per package, IATA DGR Cat 6 trained shipper). Express courier services do not accept UN1922.
Q6: What is the price of pyrrolidine?
Pricing depends on grade, packaging type, and quantity. Drum-quantity industrial grade typically falls in the USD 15-25/kg range; ISO-tank pricing significantly lower. Send your specific RFQ via the inquiry form and we'll respond with current quotation within 24 hours.
Q7: Do you supply pyrrolidine hydrochloride (pyrrolidine HCl)?
Yes - pyrrolidine hydrochloride (the salt form) is available on dedicated request. Please specify required quantity, purity, and packaging when inquiring. The free-base pyrrolidine on this product page is the parent material from which HCl salt is derived.
Q8: What payment terms do you offer?
Standard B2B terms: T/T 30% deposit + 70% balance against B/L copy or before shipment. Letter of Credit (L/C) and D/P available for first orders or large transactions. Net 30/60 terms for established accounts with credit-insurance backing. USD, EUR, and CNY invoicing available.
Q9: How do I qualify Sinolook as a supplier?
We welcome buyer audits - on-site visits, video walkthroughs, and third-party pre-shipment inspections (SGS, Bureau Veritas, Intertek). Sample shipments allow your QC team to verify against your downstream chemistry before committing to production orders. Reference letters from existing customers in your region are available on request.
Q10: How do I learn more about pyrrolidine chemistry & applications?
See our 12-article Knowledge Hub linked above - covering structure, pKa, synthesis, comparisons with pyrrole/piperidine, applications across 7 industries, safety & storage, alkaloid natural products, personal care use, the PVP polymer chain, N-substituted derivatives, APDC analytical chemistry, and the China sourcing playbook.
📩 Get Your Pyrrolidine Quote in 24 Hours
Tell us your target grade, quantity, packaging preference, and destination - we'll respond with current quotation, lead time, COA sample, SDS, and shipping plan within one business day. Sinolook Chemical has supplied pyrrolidine to 50+ countries since 2010.
🌍 Serving 50+ countries · 🏭 BDO-integrated supply chain · 📋 Full audit-ready documentation · 🚢 Worldwide shipping
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