Dimethylformamide (DMF / N,N-Dimethylformamide)

High-Purity ≥99.9% Polar Aprotic Solvent · Reliable DMF Supplier from China · Global Shipping · Full Regulatory Documentation

⛔ Critical EU Regulatory Notice - REACH Annex XIV + Repr. 1B Classification

REACH Annex XIV - Authorization Required: DMF (CAS 68-12-2) is listed on the EU REACH Authorization List as a Substance of Very High Concern (SVHC). EU manufacturers and importers using DMF in industrial processes must hold a valid REACH authorization from ECHA, or operate under an upstream authorization. The sunset date has passed - unlicensed EU industrial use is not permitted.

Repr. 1B (H360D): DMF is classified as a reproductive toxicant Category 1B under EU CLP Regulation 1272/2008. Mandatory hazard labelling, occupational exposure controls, and reproductive health risk assessment are required. Sinolook provides EU CLP-compliant SDS and REACH Annex XIV status documentation for all EU customers.

Regulatory Alternatives Available

DMF's EU REACH Annex XIV status has driven global substitution toward DMAc (N,N-Dimethylacetamide, CAS 127-19-5) and NMP (N-Methyl-2-pyrrolidone, CAS 872-50-4). For non-EU markets (US, China, India, Southeast Asia, Middle East), DMF remains widely used without Annex XIV constraints - it is not a HAP under the US Clean Air Act and is TSCA-listed. Sinolook supplies DMF, DMAc, and NMP and provides comparative regulatory documentation for all three.

What does EU REACH Annex XIV authorization mean for buyers of DMF?

REACH Annex XIV is the EU's Authorization List - substances on it require formal authorization from ECHA before continued EU industrial use after the sunset date. DMF's sunset date has passed, meaning EU industrial use without an active REACH authorization is no longer permitted. EU companies can comply by: (1) holding a REACH authorization granted by ECHA for their specific DMF use; (2) using DMF as a downstream user under an authorization held by their supplier; or (3) using DMF only in exempted uses (below 0.1% in mixtures, R&D below defined thresholds, defence exemptions). Sinolook provides current Annex XIV status documentation and connects EU customers to ECHA's authorisation process guidance.

Why does DMF have significant skin absorption - and what gloves are needed?

DMF is one of the rare industrial solvents where dermal absorption is a hazard comparable in magnitude to inhalation. Its moderate lipophilicity (log P ~−1.0) combined with its low molecular weight (73 g/mol) enables it to penetrate intact skin at measurable rates. Standard nitrile or latex exam gloves provide inadequate protection - they are permeable to DMF within minutes. Recommended glove materials are: butyl rubber (≥0.5 mm, breakthrough time typically >4 hours) or laminated barrier films such as Silver Shield or 4H gloves (breakthrough time typically >8 hours). Consult the glove permeation data in Sinolook's SDS or contact a specialist PPE supplier for specific breakthrough time data.

What is the difference between DMF and DMAc, and when should I choose one over the other?

DMF (bp 152.8°C) and DMAc (bp 165–166°C) are structurally very similar polar aprotic amide solvents with closely matched physicochemical properties. Key differences: (1) Boiling point - DMAc is ~12°C higher, preferred in processes needing a higher thermal window; (2) EU regulatory status - DMF is on REACH Annex XIV (authorization required), while DMAc is an SVHC candidate but not yet on Annex XIV; (3) Cost - DMF is typically lower cost due to simpler synthesis and higher production volume. For EU-based buyers managing REACH Annex XIV compliance, DMAc is widely adopted as a DMF substitute. Contact Sinolook for a DMAc quotation and comparative technical datasheet.

Can DMF be used in pharmaceutical manufacturing under GMP conditions?

Yes - DMF is an ICH Q3C Class 2 residual solvent (Permitted Daily Exposure 8.8 mg/day; Concentration Limit 880 ppm in drug product). DMF is widely used in pharmaceutical API synthesis in steps where downstream purification will reduce residual DMF to below ICH Q3C limits. Sinolook's pharmaceutical-grade DMF - purity ≥99.9%, water ≤0.05%, dimethylamine ≤5 ppm on request - is suitable for GMP synthesis steps where DMF is specified.

Does Sinolook offer DMAc and NMP in addition to DMF?

Yes - Sinolook supplies all three major polar aprotic amide solvents: DMF (CAS 68-12-2), DMAc / Dimethylacetamide (CAS 127-19-5), and NMP / N-Methyl-2-pyrrolidone (CAS 872-50-4). For customers evaluating solvent substitution from DMF to DMAc or NMP under REACH Annex XIV compliance pressure, Sinolook provides combined quotations, comparative technical data packages, and regulatory documentation for all three compounds.

Contact Sinolook - Your Trusted DMF Supplier

Whether you are sourcing high-purity DMF for synthetic fiber spinning, pharmaceutical API synthesis, agrochemical Vilsmeier formylation, PU coatings, or electronic chemical processing - Sinolook Chemical provides purity ≥99.9%, comprehensive regulatory documentation, and supply reliability. Contact us for a sample, DMF price quotation, or regulatory documentation package. Our team responds within 24 hours.